Wells DN, Misica PM, Tervit HR, Vivanco WH. 
Clinical and pathologic features of cloned transgenic calves and fetuses (13 case studies).
Hill JR, Roussel AJ, Cibelli JB, Edwards JF, Hooper NL, Miller MW, Thompson JA, Looney CR, Westhusin ME, Robl JM, et al. Cloned transgenic calves produced from nonquiescent fetal fibroblasts. Cibelli JB, Stice SL, Golueke PJ, Kane JJ, Jerry J, Blackwell C, Ponce de León FA, Robl JM. Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Schnieke AE, Kind AJ, Ritchie WA, Mycock K, Scott AR, Ritchie M, Wilmut I, Colman A, Campbell KH. Production of cloned calves following nuclear transfer with cultured adult mural granulosa cells. Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Wakayama T, Perry AC, Zuccotti M, Johnson KR, Yanagimachi R. Bovine inner cell mass cells as donor nuclei in the production of nuclear transfer embryos and calves. Influence of nuclear and cytoplasmic activity on the development in vivo of sheep embryos after nuclear transplantation. Nuclear transplantation in sheep embryos. Inability of mouse blastomere nuclei transferred to enucleated zygotes to support development in vitro. Viable offspring derived from fetal and adult mammalian cells. 
Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH. Links to PubMed are also available for Selected References. Get a printable copy (PDF file) of the complete article (1.4M), or click on a page image below to browse page by page. Full textįull text is available as a scanned copy of the original print version. In the meantime, veterinarians and theriogenologists have an important role to play in improving the efficiency of cloning by finding treatments to assure normal gestation to term and to develop preventative and curative care for cloned neonates. Although the cause of these anomalies remains mostly unknown, similar phenotypes have been observed in calves derived through in vitro fertilization, suggesting that culture conditions are involved in these phenomena. Research into the mechanisms involved in the reprogramming of the nucleus is being conducted throughout the world in an attempt to better understand the molecular and cellular mechanisms involved in correcting these problems. Although cloning promises great advantages for commerce and research alike, its outcome is not always certain due to high pregnancy losses and high morbidity and mortality during the neonatal period. Other applications will also undoubtedly be discovered in the near future, such as for preserving endangered breeds and species. Animal cloning is becoming a useful technique for producing transgenic farm animals and is likely to be used to produce clones from valuable adults.
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